The APPLE convened for the first time in 2010 and was attended by professionals who have abundant clinical experience in medical treatment of liver cancer in the Asia Pacific region. It was our hope that this meeting would be of substantial help to liver cancer treatments through the exchange of their clinical experience and knowledge. At the same time, by inviting internationally renowned experts in the field of liver cancer, we intended to determine the procedure for officially and internationally recognizing the treatment presently being practiced at clinics in the Asia Pacific region. We also sought to introduce new clinical studies now in progress in the field of liver cancer to overcome the problems yet unsolved and join forces with them to explore new roads.